Nitrotyrosine Impairs Mitochondrial Function in Fetal Lamb Pulmonary Ar
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چکیده
Running title: Nitrotyrosine disturbs mitochondrial function 8 9 Correspondence: Ru-Jeng Teng, M.D., Division of Neonatology, Department of 10 Pediatrics, Medical College of Wisconsin, Suite C410, Children Corporate Cen11 ter, 999N 92nd Street, Wauwatosa, WI 53226. TEL: 414-266-6820 ; Fax: 41412 266-6979 13 e-mail: [email protected] 14 15 16 17 The study was supported by CRI Start-up fund from Children’s Hospital of Wis18 consin, 2013 CTSI Pilot Award (UL1TR000055, Advancing a Healthier Wiscon19 sin), and NICHD R03HD073274 (R-J Teng); NIH R03HD-65841 and R01HL20 057268, Muma Endowed Chair in Neonatology and Children’s Research Institute 21 (to G.G.K.). 22 23 Articles in PresS. Am J Physiol Cell Physiol (October 21, 2015). doi:10.1152/ajpcell.00073.2015
منابع مشابه
Nitrotyrosine impairs mitochondrial function in fetal lamb pulmonary artery endothelial cells.
Nitration of both protein-bound and free tyrosine by reactive nitrogen species results in the formation of nitrotyrosine (NT). We previously reported that free NT impairs microtubule polymerization and uncouples endothelial nitric oxide synthase (eNOS) function in pulmonary artery endothelial cells (PAEC). Because microtubules modulate mitochondrial function, we hypothesized that increased NT l...
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Persistent pulmonary hypertension of newborn (PPHN) is associated with decreased NO release and impaired pulmonary vasodilation. We investigated the hypothesis that increased superoxide (O(2)(*-)) release by an uncoupled endothelial nitric oxide synthase (eNOS) contributes to impaired pulmonary vasodilation in PPHN. We investigated the response of isolated pulmonary arteries to the NOS agonist ...
متن کاملCALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension
Afolayan AJ, Eis A, Alexander M, Michalkiewicz T, Teng RJ, Lakshminrusimha S, Konduri GG. Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 310: L40–L49, 2016. First published October 30, 2015; doi:10.1152/ajplung.00392....
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